2025 NFL Week 2 Odds; Key Betting Lines and Matchups

The 2025 NFL Week 2 odds are out. There are 16 games this week. These include: NFL a Super Bowl rematch, divisional battles, and games that could signal early contenders. The games start Thursday, September 11th, with the Washington Commanders facing the Green Bay Packers, and wraps up with a Monday Night Football doubleheader on September 15th. Betting lines have shifted based on Week 1 results, reflecting injuries, surprises, and team adjustments. 

As always, these odds are notional and subject to change—remember, this is for informational purposes only and not intended as financial or betting advice. Bet responsibly and enjoy the games!

NFL Week 2 Highlighted Games

Here are four key matchups from Week 2, featuring tight lines, high-profile rematches, and potential for some fun like we had in week1. 

Philadelphia Eagles at Kansas City Chiefs (Sunday, Sept. 14, 4:25 p.m. ET): In a rematch of Super Bowl LIX, the Eagles open as slight road favorites against the defending champions. With a spread of Eagles -1.5, moneyline of Eagles -120 / Chiefs +100, and an over/under of 46.5, this game could be a shootout between two elite offenses led by Jalen Hurts and Patrick Mahomes.

Buffalo Bills at New York Jets (Sunday, Sept. 14, 1 p.m. ET): This AFC East rivalry pits Josh Allen’s Bills against Aaron Rodgers and the Jets. Buffalo is favored by 6.5 points, with a moneyline of Bills -320 / Jets +260 and an over/under of 46.5. 

Cleveland Browns at Baltimore Ravens (Sunday, Sept. 14, 1 p.m. ET): The Ravens, coming off a strong Week 1, are heavy favorites in this AFC North clash. Spread sits at Ravens -11.5, moneyline Ravens -900 / Browns +550, and over/under 44.5. Lamar Jackson’s squad looks to dominate, but Cleveland’s defense could keep it closer.

Chicago Bears at Detroit Lions (Sunday, Sept. 14, 1 p.m. ET): NFC North foes collide as the up-and-coming Bears visit the Lions. Detroit is favored by 5.5 points, with a moneyline of Lions -250 / Bears +210 and an over/under of 47.5. This could be a high-scoring affair with young quarterbacks Caleb Williams and Jared Goff under the spotlight.

Other close contests to watch include the Chargers at Raiders and Falcons at Vikings, where lines suggest close games. 

2025 NFL Week 2Odds Table

Here’s the 2025 NFL Week 2 odds table for you. It includes the spread, moneyline, and over/under for the game. You can also checkout our Week 2 pick-em sheet that does not include the odds here for the games. (odds via consensus from major sportsbooks like ESPN and FOX Sports):

2025 NFL Preseason and Regular Season Schedules

We have all of the 2025 NFL regular season schedules posted for you to enjoy. You can also checkout all of the individual team schedules (Regular Season) below as well as the 2026 NFL Playoff bracket and Super Bowl Schedule .

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